The purpose of the paper is to substantiate the renewed methodological aspects of interaction of natural sciences and humanities. The article has a philosophical and methodological nature and presents the analysis and synthesis of various aspects of the problem. In the course of the study, the author identifies some theoretical and methodological aspects of the ways of interaction of natural sciences and humanities in terms of the analysis of modern approaches to the issue. The results of the study can be used in building methodological approaches to further convergence of natural sciences and humanities, and constructing a unified methodological basis of scientific knowledge. The following methodological aspects of convergence of natural sciences and humanities are presented as a conclusion of the study: occurrence in natural sciences approaches, that in principle cannot give definite answers because of complexity of the system, or lack of experimental data, which results in the fact that the role of the subjective factor in the interpretation of indirect observational data or in the analysis of theoretical constructs is more and more increasing; changing perceptions of the ideal in the modern scientific era, its focus not on the search for the abstract truth, but for obtaining practical results; the development of technology leads to the need of considering the axiological components during natural sciences experiments because they can threaten both life and health of individuals and the existence of civilization as a whole; the development of various system-related theories aimed at finding some universal laws, are manifested both in natural and social phenomena.